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Indian Journal of Anesthesia and Analgesia

Volume  7, Issue 3, May-June 2020, Pages 726-733
 

Original Article

Comparision of Effects of Fentanyl and Intravenous Paracetamol on Consumption of Sevoflurane

Chiranthkumar G Nelogal, Ramachandraiah R., Mahesh KM, Satish Kumar MN, Sudheesh K.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7320.11

Abstract

Aims: The study was designed to compare the effect of IVFentanyl vs. IV Paracetamol on consumption of
Sevoflurane and the recovery characteristics.

Plan of study: Patients scheduled for elective surgeries under
general Anaesthesia are randomly allocated with 50 patients in each group. Group- F received Fentanyl
1mcg/kg per min as bolus 5min before infusion immediately after intubation. Group- P received Paracetamol
1gm in 100ml for a period of 15min and twenty five minutes before intubation. Intra-operatively Sevoflurane
concentration was titrated to maintain entropy value of 40-60. Total volume of Sevoflurane consumed
is obtained from GE/Datex-Omeda S/5 advance monitor and average Sevoflurane consumed in ml/hr is
calculated.

Results: Consumption of Sevoflurane in Group- F was 16.01 ± 0.95ml/hr as compared to 16.9 ± 2.2
ml/hr in Group- P which was statistically significant. Post extubation at the end of fifth minute all patients in
Group- P attained score of 12 as compared to only 56% patients of Group- F and it was is statistica lly significant
(p <0.001).

Conclusion: Consumption of Sevoflurane & post-operative pain was less in Fentanyl group when
compared to paracetamol group. However recovery characteristics are better in paracetamol group.


Keywords : IV Paracetamol, IV Fentanyl, Consumption of Sevoflurane, Entropy.
Corresponding Author : Mahesh KM