Introduction: Cholecystectomy is surgical removal of the gall bladder. Intraperitoneal administration of other drugs along with the local anesthetics will reduce the consumption of supplementary postoperative analgesic medication. Aims: To compare between MgSO4 and Tramadol when used along with Intraperitoneal Local Anesthetics (IPLA) by instillation of drug for postoperative pain relief in terms of Visual Analog Scores. Materials and Methods: Prospective analytical study in Sixty adult patients of Class I and Class II as per American Society of Anesthesiology (ASA) of either sex were posted for elective laparoscopic cholecystectomy. These patients participated in prospective open randomized study for postoperative pain relief after laparoscopic cholecystectomy. Results: Bupivacaine along with Magnesium sulphate instillation significantly reduced VAS pain scores over 24 hrs. Prolonged duration of analgesia was noted with Magnesium sulphate. Total analgesic required over 24 hrs was less with Magnesium use. No signs of drug allergy and toxicity were observed. Conclusions: Bupivacaine and Magnesium sulphate are safe and efficacious in reducing postoperative pain following intraperitoneal instillation in laparoscopic surgeries. Thus, the intraperitoneal instillation of Bupivacaine-MgSO4 combination provides good analgesia in first 24 hours after surgery, with longer duration of pain free period.