Advertisement!
Author Information Pack
Editorial Board
Submit article
Special Issue
Editor's selection process
Join as Reviewer/Editor
List of Reviewer
Indexing Information
Most popular articles
Purchase Single Articles
Archive
Free Online Access
Current Issue
Recommend this journal to your library
Advertiser
Accepted Articles
Search Articles
Email Alerts
FAQ
Contact Us
Indian Journal of Anesthesia and Analgesia

Volume  7, Issue 1, January-February 2020, Pages 58-63
 

Original Article

A Comparative Study of Neuromuscular Blocking Effects and Reversibility of Cisatracurium and Vecuronium

Divya N Kheskani, Heena S Chhanwal, Bhakti S Jain

1Assistant Professor, 2Professor and Head, 3rd Year Resident, Department of Anaesthesia, GCS Medical College, Hospital & Research Centre, Near Chamunda Bridge, Ahmedabad, Gujarat 380025, India.

Choose an option to locate / access this Article:
60 days Access
Check if you have access through your login credentials.        PDF      |
|

Open Access: View PDF

DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7120.9

Abstract

Context: Cisatracurium is a cis isomer of parent compound atracurium, devoid of histamine release, thus possessing hemodynamic & cardiovascular stability. Aims: We compared the intubating conditions, hemodynamic stability & recovery of atracurium & vecuronium. Settings and Design: We carried out prospective, double blind randomized study after approval of ethical committee. 100 adult patients of ASA 1 & 2 with comparable demographic data were selected. Divided in Two Groups C (Cisatracurium) & V (Vecuronium). Standard monitoring was done & following routine premedication & induction agents, patients were intubated at 2 mins after administration of cisatracurium 0.15 mg/kg & vecuronium 0.1 mg/ kg respectively, maintained on intermittent dose of cisatracurium: 0.03 mg/kg & vecuronium: 0.02 mg/kg. Intubation conditions were assessed according to Time to 25% recovery of t1/tc following initial doses, Time to 25% recovery of t1/tc following repeated boluses, Time to 25% recovery of t1/tc following last dose, Return of t4/t1 ratio 0.8 spontaneous recovery at end of operation. Statistical analysis used: The results were evaluated by applying paired t-test and p - value using SPSS Statistical Software. Results: Intubating conditions at 2 mins following administration appeared satisfactory & laryngoscopy condition was good in 98% in Group C & 97% in Group V, Time taken for 25% recovery following First Dose & Subsequent Doses was longer for Group C than Group V. Time taken to 25% recovery of t1/tc following Last Dose was shorter in Group C patients as compared to Group V, duration of action of Group C was longer than Group V, both demonstrated equal hemodynamic & cardiovascular effect. Conclusions: Cisatracurium is intermediate onset nondepolarizing muscle relaxant devoid of histamine release with longer duration of action & faster recovery.

 


Keywords : Cisatracurium; Vecuronium; Intubating conditions; Recovery; Hemodynamic profile.
Corresponding Author : Heena S Chhanwal