Background and Introduction: Congenital malformations may be defined as any anatomical defect, single or multiple, present at birth, attributable to fault in development. The severity of such a defect may vary from symptomless and regressible capillary naevi to lethal multiple system defects. A combination of genetic, biologic and environmental factors is considered to be responsible for many of these conditions. Materials and Methods: The study was carried out in the Obstetrics & Gynecology department of a tertiary care hospital in Southeastern India. The period of study was taken as per the protocol of the project. It was a hospital based observational study not involving any surgical intervention. Observation and Results: A total of 7268 babies were delivered during this period in the Department of Obstetrics and Gynecology, (both live and still born). Out of these 116 (one hundred and sixteen) babies were found to have congenital malformations including both major and minor malformations. In the present study, the commonest system involved was the musculoskeletal system (22.4%). The commonest malformations of the musculoskeletal system observed in the present study were talipes (15cases) and polydactyly (8 cases). Conclusion: Congenital malformations constitute one of the important causes of morbidity and mortality in the neonatal period, affecting nearly 1.59% of the newborns and contributing to many of the prenatal deaths.