Advertisement!
Author Information Pack
Editorial Board
Submit article
Special Issue
Editor's selection process
Join as Reviewer/Editor
List of Reviewer
Indexing Information
Most popular articles
Purchase Single Articles
Archive
Free Online Access
Current Issue
Recommend this journal to your library
Advertiser
Accepted Articles
Search Articles
Email Alerts
FAQ
Contact Us
Indian Journal of Anatomy

Volume  7, Issue 2, Mar-Apr 2018, Pages 215-217
 

Case Report

Schizencephaly: A Neuronal Progression Disorder

Junagade Bhavana S.1, Sabnis Anjali S.2

1 Assistant Professor 2 Professor and Head, Department of Anatomy, MGM Medical College, Kamothe, Navi Mumbai, Maharashtra, India.

Choose an option to locate / access this Article:
90 days Access
Check if you have access through your login credentials.        PDF      |
|

Open Access: View PDF

DOI: http://dx.doi.org/10.21088/ija.2320.0022.7218.19

Abstract

Schizencephaly is a congenital cleft in cerebral mantle extending from pial surface to the lateral ventricle. It is lined by heterotopic grey matter. It is rare, with a prevalence of 1.48/1,00,000 births. In this case study, adult female brain specimen showed unilateral open lipped cleft - schizencephaly, in the left hemispheric perisylvian region communicating with the left lateral ventricular cavity. Cleft was lined by heterotopic grey matter. Schizencephaly is considered as the neuronal progression or migration disorder. It is also thought to be a brain segmentation disorder. This disruptive birth defect may have ischaemic - vascular injury at its root or it could be a presence of infection like Cytomegalo virus. Mutations in Homeobox gene EMX2 have been also implicated in this congenital anomaly. Our study indirectly confirms that unilateral cases of Schizencephaly may lead long life remaining undiagnosed till death.

 

 


Keywords : Unilateral Cerebral Cleft; Perisylvian; Open Lipped Cleft; Heterotopia. 
Corresponding Author : Junagade Bhavana S., Assistant Professor, Department of Anatomy, MGM Medical College, Kamothe, Navi Mumbai, Maharashtra, India.