Background: Chronic cholecystitis is one of the most commonly encountered lesions in India and worldwide. Cholecystitis, cholelithiasis and tumors of gall bladder constitute the bulk of gall bladder diseases among which gall stones being the most common. Long standing chronic inflammation due to gall stones is considered as an important etiological factor in carcinogenesis. This study was carried out to correlate clinical & histopathological findings of gall bladder lesions. Materials and Methods: This study included 120 cases that underwent for open or laproscopic cholecystectomy for cholecystitis, cholelithiasis or suspected cases of malignancy. Clinical details were collected. Formalin fixed tissues were embedded in paraffin, cut into thin sections and stained with haematoxylin and eosin (H&E) for studying the histopathology. Results: Out of total 120 cases maximum were females 98 (81.66 %), and 22 (18.33 %) males. Maximum cases were seen in 4th to 6th decade. Maximum cases were diagnosed as chronic cholecystitis. Other associated findings like xanthogranulomatous change, intestinal metaplastic change, and follicular cholecystitis were seen. Total six cases of adenocarcinoma was diagnosed out of which five cases showed features of well differentiated adenocarcinoma and one case showed papillary pattern. on histopathology examination. Interpretation and conclusion: Gall bladder diseases can have a varied presentation on both clinical and histopathological examination. The present study showed a female predominance. Cholelithiasis proved to be a major risk factor for inflammatory diseases. Constant erosion of the gall bladder wall by gallstones over a long period may constitute a risk for malignancy.

Keywords: Gall Bladder Histology; Gall Bladder Lesions; Cholecystitis; Adenocarcinoma.