Aims: 1. To study the shape and size of normal pituitary gland with respect to both the lobes in all age groups of both genders by studying MRI images of brain. 2. To determine and evaluate mean normal size and shape of normal pituitary gland with relation to age and gender. Setting and Design: For the study MR images all ages were used to characterize the effect of age and sex on pituitary size and shape. All the three dimensions of both the lobes of pituitary gland and stalk were measured using mid sagital and axial MR images. Methods and Material: Images of 160 living subjects (76 females and 84 males) of all ages were used. By using electronic caliper all above mentioned parameters were measured. Statistical Analysis Used: The data was grouped in age group 0-10, 11-20, 21-50, >51 years of both the genders, analyzed by One way ANOVA test, unpaired t-test. For shape of gland percentage and Chi-square test used. Results: The dimensions were steadily increased up to 21-50 years group later decreased. The changes were noted statistically significant. Also significant change in shape. More convex up to 50 yrs then become concave. Conclusion: This study demonstrated the database all age groups, which was its mean size and shape of both lobes of pituitary gland, can apply for clinical evaluation.

Keywords: Pituitary gland; MRI, anterior and posterior lobe; Shape.