Context: MEWS score is a simple, physiological score that may allow improvement in the quality and safety of management provided to patients. Aims: The aim of the study is to evaluate the effectiveness of structured teaching program on level of knowledge regarding MEWS score among student nurses. Methods and Material: The research design used in this study was one group pre-test and post-test Pre experimental design and conducted in selected Nursing College, Amritsar. Convenient sampling technique was used to select 30 student nurses. Structured knowledge questionnaire was used to before and after structured teaching program. Statistical Analysis used: Collected data were coded, tabulated and analysed by descriptive and inferential statistics. Results: Majority of the student nurses participated in the study belonged to 21–22 years of age (46.7%), Sikh religion (56.7%) and from rural area (56.6%). Most of the student nurses had monthly income of `10001–15000/- (43.3%) and got knowledge from multimedia (70%). The study findings revealed that in pre-test majority of the student nurses (53.3%) had inadequate knowledge whereas in post-test majority (56.7%) had adequate knowledge regarding MEWS score. The mean score was 6.80 in pre-test and 15.53 in post-test. The ‘t’ value 11.25 which was highly significant at 0.01 level. Hence hypothesis (H1) is accepted. There was no significant association between posttest knowledge score with selected demographic variables of student nurses. Conclusions: Based on statistical findings, it is evident that the provision of structured teaching programon MEWS score has increased the knowledge of student nurses.