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International Journal of Forensic Science

Volume  5, Issue 1, January-June 2022, Pages 9-18
 

Original Article

Extraction and Identification of Dothiepin, Paroxetine, Thioridazine and Trifluoperazine in Blood by Thin Layer Chromatography using Different Solvent Systems

Pallavi Choudhary1, Anusha Srivastava2, Kanak Lata Verma3, A K Jaiswal

1Junior Forensic Assistant Chemical Examiner, 3Assistant Director, Regional Forensic Science Laboratory, Home Department, Government of NCT of Delhi, Chankyapuri, New Delhi 110021, 2Intern, Centre of Forensic Science, Banaras Hindu University, Uttar Pradesh 221005, India, 4Chemist, Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

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Abstract

An attempt has been made to develop a new thin layer chromatographic method for analysis of ‘Dothiepin, Paroxetine, Thioridazine and Trifluoperazine’ in blood using different solvent system as mobile phase. ‘These antidepressant and antipsychotic drugs’ were extracted from blood samples using liquid-liquid extraction method and analysed by Thin Layer Chromatography. 15 different solvent systems with different concentration were introduced and various TLC plates were run in these solvent systems. The Developed plates were viewed under UV light 254 nm followed by spray of chromogenic reagent i.e., Dragendorff’s Reagent which efficaciously amplified the sensitivity without upsetting simplicity of the method. The observations in each case were thoroughly analysed and reported. The developed method is a simple, rapid, low-cost, non-destructive and reproducible which can be performed in any laboratory easily.


Corresponding Author : Pallavi Choudhary