Introduction: Trapezitis is defined as the ‘inflammation of trapezius muscle’. The upper trapezius muscle designed as postural muscle and its highly susceptible to overuse. people who use their arms for extended periods of time that requires holding their arms out in front, like operating mobile, computer, bike riding, car driving or an assembly line worker will recognize a burning pain between the shoulder blades. Myofascial release which eliminates the fascia's excessive pressure on the pain sensitive structure and restores proper alignment. Hence this technique is proposed to act as a catalyst in cupping therapy (CT) a traditional chinese medicine therapy, has used for >2000 years and uses a negative pressure mechanism the resolution of trapezius spasm. Aim: The aim of study is to compare the effectiveness of cupping therapy vs. myofascial release technique in trapezitis caused by digitalization. Method: Total 30 patients were included in the study by simple random sampling method. Subjects were divided into two groups with 15 patients in each group. Group A was receive UST with myofascial release technique, Group B was receive UST with cupping therapy. The patient has assessed pre and post intervention through visual analog scale (VAS), neck disability index (NDI), and cervical range of motion (CROM). Result: Data was analyzed by using paired t-test. Pre and post score were taken via VAS, NDI, and CROM. P value <0.05. Conclusion: The study concluded that both the groups has shown significant improvement in reduction of pain and improve functional limitation and range of motion. However MFR with UST has shown a better improvement than cupping therapy with UST when the subjects in both the groups are compared.