Introduction: Oral cancer is 1/10 mainly widespread cancers in the world. Its high frequency in Central and South East Asian countries like India, Bangladesh, Sri Lanka Thailand, Indonesia, Pakistan, has been well documented.2 It is estimated that during the year 2008 about 2.6 lac new cases and 1.27 deaths occurred worldwide, with a mortality 1.9 per lac population. Burden of oral cancer in India, 20/1,00,000 population are pretentious by oral cancer which is about 30% of all types of cancer. Over 5 people in India die every hour every day because of oral cancer and the same number of people dies from cancer in oropharynx and hypo pharynx.1 Cancer listing is not necessary in India, so the true incidence and mortality may be higher, as many cases are unrecorded and loses follow up. None of the national registry provides cancer incidence or mortality data for India.4 Objectives: (1) To assess the Pre-test and post-test knowledge mean of nursing students regarding prevention of oral cancer at selected Institute. (2) To assess the effectiveness of structured teaching regarding prevention of oral cancer at selected Institute. (3) To find out the association between pre test knowledge mean of nursing students with selected sociodemographic variables of nursing students. Results: The results of the study indicates that structured teaching programme was effective in this study for improving the knowledge of the nursing students. The result obtained for posttest mean and standard deviation more over the ‘Z’ value obtained was found to be significant at 0.05 level thus it can be concluded that structured teaching programme was effective in increasing the level of knowledge regarding prevention of oral cancer. The mean percentage difference was 24.45% thus the hypothesis is accepted. Another finding of study was that there is an association between knowledge level of nursing students with their selected sociodemographic variables undergoing structured teaching programme at significant 0.05 level so the hypothesis is accepted. Conclusion: Prevention is better than care. As statical data shows that it is a global burden in India to prevention our population for oral cancer that is the highest rate of cancer in India. As nursing students are the health care provider so education is important to pathway of prevention