Depression is a potentially preventable disease if appropriate screening and prophylactic strategies are employed. However, lack of knowledge and awareness can result in underutilization of the preventive strategies. We assessed the knowledge among men and women in selected old age home of surat district. We conducted a comparative study on men and women of selected area. Data were collected using a survey method and self-administered questionnaire related to geriatric depression scale. Data analysis was done using descriptive and inferential statistics. Results: Data from 60 participants were included in the final analysis. Difference between men and women was 3.7, the median difference between men and women was 4.1, the mode difference between men and women was 2, the standard deviation difference between men and women was 0.54. That is indicate men have more depression rather than women. Conclusions: Our study population showed depression of men and women. Preventive interventions including education for individuals with chronic illness, behavioural activation, cognitive restructuring, problem solving skills training, group support, and life review have also received support.