Anaemia is a condition in which the number of red blood cells and consequently their oxygen-carrying capacity is insufficient to meet all the body’s physiologic needs which are vary with a person’s age, gender, altitude, smoking and different stages of pregnancy. Iron deficiency is thought to be the most common cause of anaemia globally, but some other nutritional deficiencies (including folate, vitamin B12 and vitamin A), acute and chronic inflammation, parasitic infections, and inherited or acquired disorders can cause anaemia. Methodology: Quantitative non-experimental Descriptive research design was used. The targeted population is adolescent girls age group (12–19 years). 60 subjects were collected using convenient sampling technique. The tool used to collect data is structured questionnaire prepared by the researcher. Result: Out of 60 subjects, majority of them 53.3% has average knowledge on prevention and management of anaemia, 36.7% of them had good knowledge and 10% of them had poor knowledge. There was statistically significant association between the level of knowledge with selected demographic variables as age at p > 0.05 level. Conclusion: Therefore the findings of the study revealed that knowledge regarding prevention of anaemia among adolescent girls were at average level. It revealed that the role of community health nurse plays vital role in promoting the level of knowledge on prevention and management of anemia among adolescent girls to rule out anemia