Amoebic liver abscess is an important cause of inflammatory space occupying lesion of liver. This study is conducted to know the clinical presentation, management and efficacy of conservative management and percutaneous aspiration in amoebic liver abscess. Materials and Methods: A total of 30 patients of amoebic liver abscess were selected for the study in Vydehi Institute of Medical Sciences and research centre, Bangalore. Their clinical presentation, lab findings and treatment in the form of conservative (abscess <5 cms ) and ultrasound guided percutaneous aspiration (abscess >5 cms) were studied. Results: The amoebic liver abscess was common in low socioeconomic middle aged male patients. Pain and fever were the most common symptoms. USG abdomen was useful in early diagnosis and assessing prognosis. Most of the abscess was solitary common in right lobe of liver. Liver function tests helps in knowing effectiveness of the treatment and the prognosis. None of the patients were positive for cysts in the stool. 27 (90%) patients were positive for anti amoebic antibody. Conservative management was effective with cavities <5 cms. Percutaneous aspiration was effective with cavities >5 cms. There was one mortality. Conclusion: Amoebic liver abscess commonly seen in young to middle aged males. Ultrasonography helps in early diagnosis. Abscess <5 cms are effectively treated by conservative management and abscess >5 cms by percutaneous aspiration. Resolution of abscess faster in patients treated by percutaneous aspiration as compared to conservative treatment.