AbstractManagement of Infected Diabetic wounds is fundamental in surgical practice. Diabetic ulcers have variable infective etiology and many dressing agents are used for local application. EUSOL and Acetic Acid are commonly used for slough removal over infected ulcers. Aim of the study is to determine the efficacy of EUSOL and Acetic Acid in removal of slough over Diabetic ulcers infected with Proteus, Pseudomonas and other Bacterial growth. This study was conducted in the Department of General Surgery at PES institute of medical science & research, Kuppam, Chittoor District, Andra Pradesh in the period between September 2017 to March 2018 over a study population of 30 patients. 15 patients with Pseudomonas culture positive ulcers and remaining 15 with other bacterial growth positive ulcers and dressings done with Acetic acid and EUSOL respectively and findings noted in terms of slough removal and formation of granulation tissue. By this study We recommendthe selection of suitable solution (Acetic acid for Pseudomonas and EUSOL for other bacterial growth) that helps in quick slough removal and wound healing.