High dose Stosstherapy (600000 IU intramuscular vitamin-D) is being used since 1930 to treat nutritional rickets. However, lack of treatment guidelines and inadequacy of studies evaluating it’s safety, efficacy and follow-up schedule has led to wrong practices. Physicians give multiple vitamin-D injections using alkaline phosphatase as a surrogate marker, leading to the possibility of vitamin-D toxicity. This along with frequent follow-up biochemical and radiological tests increases the cost of therapy and negates Stosstherapy’s main advantage of better compliance.
: Daipayan Chatterjee