Background: Gastric Outlet Obstruction may be caused by a heterogeneous group of diseases that include both benign and malignant conditions. In adults, mechanical obstruction due to ulcers, tumors or gastric polyps are common causes of gastric outlet obstruction. Until introduction of effective ulcer therapy duodenal ulcer was the commonest cause of gastric outlet obstruction and malignancy was attributed to only 20% of the cases.

Objectives: To study the modes and presentation of presentation of gastric outlet obstruction among patients suffering from Duodenal ulcer diseases.

Materials and Methods: A Hospital based Prospective study was conducted at Tertiary Care Centrefrom October 2017 to September 2019. A total of 100 cases of Gastric outlet obstruction were diagnosed during the study period. An elaborate study of these cases with regard to the history, clinical features, routine and special investigations, pre-operative treatment, operative findings, postoperative management and complications in post-operative period is done.

Results: A total of 100 cases with gastric outlet obstruction were analyzed in our study. Out of the 100 cases with gastric outlet obstruction, 28 (28%) were diagnosed with cicatrizes duodenal ulcer and 72 (72%) of them had carcinoma antrum. Majority of the study subjects presented with pain, vomiting and anorexia on admission. Pallor was seen in nearly 68% of the study subjects followed by 56% of the cases with VGP and 54% with succession Splash. Only 28% of the subjects had palpable mass on palpation.

Conclusion: Upper Gastro intestinal endoscopy should be mandatory in all suspected cases of gastric outlet obstruction. It can diagnose the cause of obstruction very effectively than any other investigative modality. Effective treatment in carcinoma stomach depends on early diagnosis.