Background: Bio medical waste (BMW) collection and proper disposal has become a significant concern for both the medical and general community. Effective management of biomedical waste is not only a legal necessity but also a social responsibility. Aims and Objectives:The present experimental descriptive studywas conducted to “a study to assess the effectiveness of planned teaching program on biomedical waste management among staff Nurses working in Dr. Vikhe Patil Memorial Hospital Ahmednagar”. The data were collectedby using the self-preparedstructured knowledge questionnaire. The results were analyzed and interpreted using descriptive, inferential statistics and Paired ‘t’ test. Results: Result revealed that Paired ‘t’ test of correlation analysis between pre test and post test scores shows that there is significant relationship (t; 12.04) which reveals positive relationship between variables. Hence it can be interpreted that the planned teaching programme on biomedical waste management is effective among staff nurses. Thus the stated null hypothesis (H02) was rejected.Conclusion: It is essential to raise awareness on biomedical waste management and its impact on health; and develop health seeking behaviors among the patients and improve the quality of life.