Introduction: Transurethral resection of prostate and prostatic biopsies are very common specimens in surgical pathology. Prostatic biopsies are done in cases where there is clinical suspicion of malignancy. These specimens have to be thoroughly examined to avoid false negative diagnosis of adenocarcinoma prostate. Non-neoplastic lesions which are to be distinguished from adenocarcinoma prostate are atrophy including partial atrophy, atypical adenomatous hyperplasia (adenosis), crowded benign glands, sclerosingadenosis, radiation atypia in benign glands, basal cell hyperplasia, clear cell cribriform hyperplasia, non-specific granulomatous prostatitis, dense inflammation and malakoplakia. Aims and objective: The aims of this study is to evaluate the spectrum of histomorphological lesions of prostate and evaluating them with them help of Immunohistochemisry (IHC) markers such as P63 and AMACR. Material and methods: A total of 100 TURP and 20 needle biopsies were collected and examined each under light microscopy for benign, premalignant, and malignant lesions. All the biopsies are stained with H&E and doubtful lesions were stained with P63 and AMACR. Results: Total 90 were benign in TURP and 6 in biopsies specimen. Low grade pin was found in TURP biopsies amounting to 10% and 4% HGPIN in vicinity to neoplastic glands. Most common gleasons scoring was 7. IHC was done, AMACR was positive in HGPIN and in adenocarcinoma and p63 was focally disrupted in HGPIN and totally absent in adenocarcinoma. Conclusion: The substantial proportion of patients undergoing TURP and biopsies for clinically symptomatic benign enlarged prostate emphasizes the need for early diagnosis through histopathological examination.

Keywords: BPH; Carcinoma prostate; PIN; P63 and AMACR.