Objective: The most widely accepted hypothesis is bile stasis caused by gall bladder dyskinesia. The aim of this study is to investigate about relationship between gall stones and different gall bladder pathologies. Methods: Specimens for study was sent by surgery department for histopathology after cholecystectomy. After grossing, sections were submitted for tissue processing. Results: Grossly, size of gall bladder was normal in 91 (60.66%) but fibrotic in 15 (10%) and enlarged in 44 (29.34%) patients. Wall thickness was normal (<3 mm) in 79 (52.67%) and thickened (>3 mm) in 71 patients (47.33%). In microscopy 110 (73.34%) were of chronic cholecystitis, cholesterolosis 15 (10%) cases, xathogranulomatous and acute on chronic cholecystitis 3 cases (2%) each, 1 case (0.67%) each of mucocele and follicular cholecystitis. Hyperplasia was observed in 8 (5.33%) cases. Hyperplasia subclassified into adenomatous and adenomyomatous. Five (3.33%) cases of cholecystitis with metaplasia were seen. There were 4 cases (2.66%) of carcinoma, predominant histologic type being adenocarcinoma. Conclusion: Presence of stones may lead to different mucosal changes from chronic inflammation to carcinoma. Therefore histopathological examination of all cholecystectomy specimens with or without cholelithiasis is essential to diagnose benign as well as malignant pathology.

Keywords: Cholecystitis; Dysplasia; Hyperplasia and Metaplasia.