Introduction: We studied effectiveness of PDCA cycle in improving compliance of laboratory staff with respect to universal safety precautions. Material and Methods: We noted compliance of staff to safety precautions like wearing apron, gloves, hand wash, avoiding eating and drinking in the lab before and after the institution of PDCA cycle for a period of 1 month. The significance of difference was calculated using Chi squared test. Results: We found significant improvement in avoiding eating and drinking in lab (p: < 0.0001), wearing apron (p: < 0.012), wearing hand gloves (p: < 0.000423), hand wash (p: <0.001). Conclusion: PDCA technique is effective in improving compliance to universal safety precautions and can be applied in bigger scale for other problems.

Keywords: PDCA; Universal safety precautions.