Aims: To determine the histopathologic correlation of breast FNAC. Settings and Design: This is a two-year prospective study of breast lumps seen at Department of Pathology, Dr. S.N. Medical College, Jodhpur (Rajasthan) between June 2011 and June 2013. Methods and Material: A total of 526 FNAC cases were evaluated. Histologic follow up was available for 173 FNAC samples. Statistical analysis used: The cytological diagnoses were categorised into one of five diagnostic categories in accordance with the National Health Services Breast Screening Programme of Britain classification (C1, C2, C3, C4, & C5). Then cytological findings were correlated with histological findings and accuracy was assessed by calculating sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, predictive valve, false negative, false positive rates and accuracy. Results: Between June 2011 to June 2013 a total of approximately 526 FNAC breast cases were evaluated. Histologic follow up was available for 173 FNAC samples. Amongst all the cases (526) reported in cytology, maximum cases i.e., 417 (79.28%) cases had C2 lesions. Out of 526 FNAC cases, 173 were correlated in histology. So, in total there were 3 false positive cases and 4 false negative cases in this study. Results calculated were: sensitivity= 89.47%, specificity= 97.78%, positive predictive value= 91.89%, negative predictive value= 97.06% and accuracy= 95.95% Conclusions: A high sensitivity and a high positive predictive value proved that a positive FNAC in the breast means a definite diagnosis of the concerned pathology when compared with the final histology report. The high specificity and a high negative predictive value for malignancy illustrated the high accuracy of FNAC in the diagnosis of malignancy in the breast.

Keywords: FNAC; Histopathology; Correlation; Sensitivity; Accuracy.