Aim: To delineate the histopathological pattern of prostate diseases and to correlate prostate speci c antigen values and histomorphological features. Methods and materials: A retrospective review was made of all prostate biopsy reports seen between January 2013 to December 2017 at Department of Pathology, Khaja Banda Nawaz Institute of Medical Sciences Kalaburagi, Karnataka. A total number of 164 biopsies was received at the department of pathology. All prostate biopsies were classi ed as In ammatory and neoplastic lesions which comprise benign prostatic hypertrophy and carcinoma. Prostate speci c antigen values were analyzed documented and correlated with histopathological  ndings. Hematoxylin and eosin stained sections were examined using paraf n embedded blocks. Results: Mean age of presentation was 60.5±12.5yrs with maximum incidence in 7th decade of life. Out of 164 biopsies examined 85.97% (141cases) were diagnosed as benign prostatic hyperplasia with or with out prostatitis, Two cases were diagnosed as High grade Prostatic intraepithelial neoplasia [1.23%] and 21 cases were adenocarcinoma [12.80%]. The most common gleason score was 7 (71.42%) followed by score 9 (19.04%). and score 4 (9.52) .Pattern 4 was most common predominant. Most adenocarcinoma is well differentiated to moderately differentiate with Gleason’s score of 4 to 9. Prostate speci c antigen [PSA] is used as screening test for prostate carcinoma with PSA value in range from 4 to 140ng/ml. Conclusions: In this study, 1. Benign Prostatic hyperplasia is commonest benign lesion and adenocarcinoma is histopathological type of prostate cancer. 2. Prostate speci c antigen [PSA] was in higher range in prostate cancer than in Benign Prostatic hyperplasia, hence PSA is good early indicator for malignancy 3. Histopathology examination remains the diagnostic test for con rmation of malignancy

Keywords: Prostate Adenocarcinoma; Benign Prostatic Hyperplasia; Prostate Specific Antigen.