Background: The primary lung lesion includes both neoplastic and non-neoplastic conditions. However lungs can secondarily involved in almost all forms of terminal events. Many times clinical and radiological findings in respiratory diseases are nonspecific, so prompt pathological investigation and diagnosis is essential. Autopsy is an important tool for identifying and understanding respiratory diseases Aims & Objectives: To know the histopathological spectrum of Lung diseases and frequency of pulmonary lesions in respect to age and sex. Material & Methods: The study was done on 250 lung specimens from autopsy cases received in the Department of Pathology, Bangalore medical College for a period of 1year during January 2014 to January 2015. Gross findings and microscopic features were recorded. Results: The spectrum of lung lesions were seen, the commonest being edema and congestion 90 (36%) followed by pneumonia 80 (32%), Emphysema 20 (8%), Tuberculosis 18 (7.2%) , Acute respiratory distress syndrome 12 (4.8%), Amniotic fluid embolism 5 (2%), Pulmonary embolism 3 (1.2%) and Lymphoma 2 (0.8%). In 20 (8%) cases we saw normal lung histology. Conclusion: The present study is making an attempt to study the various spectrum of lung lesions, in where infectious lesions (nontubercular & tubercular pneumonias) are still the most common preventable causes of morbidity and mortality. Hence, autopsy study can be of great value in improving the vision and diagnostic setups for better clinical assessment, timely diagnosis and therapy.

Keywords: Lung Autopsy; Pneumonia, Tuberculosis; Histomorphological Pattern.