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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.71118.8

Abstract

Context: Endometrial carcinoma is one of the most common malignancies occurring in postmenopausal females. Endometrial carcinomas are of two types, type I and type II. Type I is the most common encountered type of endometrial carcinoma. Aim: The aim of this study was to study the spectrum of histomorphology of endometrial carcinomas with special reference to immunohistochemical findings including ER PR and p 53. Methods and Material: This was a prospective study conducted over a period of eighteen months. Thirty cases of endometrial carcinomas were included in the study. The diagnosis of endometrial carcinoma was confirmed after microscopic examination. Immunohistochemical expression of ER, PR and P53 was studied. Statistical analysis: Correlation between the histopathological results and immunohistochemistry results were calculated by using chi square tests and test of sample proportion. Results: The association of histologic type I of endometrial carcinoma with estrogen receptor and progesterone receptor was significant with the p value less than 0.01 and 0.05 respectively. The association of histologic type II of endometrial carcinoma with p53 was significant with the p value less than 0.05. Conclusion: In the present study, significant association was noted between estrogen and progesterone receptor in type I endometrial carcinoma and between type II endometrial carcinoma and p53. The expression of ER and PR were found to be related to disease recurrence, reports suggest that ER, PR and p53 status, as determined by IHC, can be used as an independent predictor for disease recurrence. 

 

Keywords : Endometrial Carcinoma; Types; Immunohistochemical Study of ER; PR P53. 

Corresponding Author : Priyanka P, Assistant Professor, Department of Pathology, Shri Sathya Sai Medical College And Hospital, TiruporurGuduvancherry Main Road, Ammapettai, Chengalpet Taluk, Kancheepuram District, Nellikuppam, Tamil Nadu 603108, India.