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Indian Journal of Pathology: Research and Practice

Volume  7, Issue 10, October 2018, Pages 1095-1098
 

Original Article

Intraoperative Squash Cytology of Central Nervous System Lesions: Review of an Eight-Year Experience

Nalinimohan C.1, Padmaja K.2, Shailaja P.3, Deshpande A.K.4

1,2Associate Professor 3Professor 4Professor and Head, Department of Pathology, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana 500068, India.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.71018.9

Abstract

 Background: Intraoperative squash cytology is a simple and reliable technique for rapid intraoperative diagnosis of neurosurgical specimens. Intraoperative squash cytology is a fairly accurate diagnostic modality which can be used in place of frozen sections. Aim: To assess the diagnostic accuracy of the squash preparation and to compare it with the histopathology sections. Materials and Methods: This study was conducted over a period of eight 8 years (May 2010 to June 2018) which included 131 patients with CNS lesions. The cytological preparations were stained by the rapid H & E method. The squash interpretation was compared with the paraffin section diagnosis. Results: Of the 131 patients, Squash cytology diagnosis was offered in all the cases. With hematoxylin and eosin-stained histopathology sections as the gold standard, the diagnostic accuracy of squash cytology was 95.4% (125/131). Among these cases, gliomas formed the largest group comprising of 50 cases (38.1%). The accuracy of squash cytology in this group was 94% (47/50). Conclusions: CNS squash preparations can be used for rapid and reliable intraoperative diagnosis for CNS lesions. 

Keywords: Central Nervous System Lesions; Intraoperative  Diagnosis; Squash Preparation.


Corresponding Author : Padmaja K, Associate Professor, Department of Pathology, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana 500068, India.