Cutaneous reactive angioendotheliomatosis (CRA) is a group of benign skin disorders which comprise 3 main entities: reactive angioendotheliomatosis (RAE), intralymphatichistiocytosis and diffuse dermal angiomatosis (DDA). These disorders are characterized by vascular proliferations which are either intraluminal or periluminal. Of these, RAE is well known to arise in association with chronic systemic disorders. We report a case of a 37 year old female, who presented with multiple, painless skin coloured nodules over the extensor aspect of her upper limb and foot. She also had multiple painful, erythematous nodules over the upper as well as lower limb. Light microscopy of the painless nodules, showed features suggestive of RAE. The painful,erythematous papules of the upper limb, showed features consistent with Borderline Lepromatous Leprosy. Immunohistochemistry with CD31 and CD34 showed positivity of the spindle cells lining the capillaries, proving its vascular origin. To our knowledge, this is the first case to be reported of RAE occurring in the setting of leprosy.

Keywords: Reactive Angioendotheliomatosis; Leprosy; Skin.