AbstractContext: Anaemia is defined as reduction below normal limits of the total circulating red cell mass. It is measured by the reduction in packed red cell volume or reduction in haemoglobin concentration of blood. Blood transfusion will be helpful in the correction of anemia.
Aims: This study is aimed at evaluating the effect of packed red cells transfusion in anemic patients by comparing pre and post transfusion hematological work up.
Methods and Material: The present study was done in the department of pathology comprised of 130 anaemic patients who received packed red cell transfusion in Sri Manakula Vinayagar Medical College and Hospital. Data was collected from September 2012 to May 2014. Haematological parameters were collected by automated haematology analyser. Peripheral smear and reticulocyte smear were made.
Statistical Analysis used: Mean, standard deviation was done using Epi Info software. P value was calculated using paired test. Microsoft word and Excel have been used to generate graphs, tables etc.
Results: Out of 130 patients, 45 (34.6%) were iron deficiency anaemia followed by 43 (33.1%) anaemia of chronic disease, 18 (13.8%) anaemia of chronic kidney disease, 10 (7.7%) anaemia of liver disease, 10 (7.7%) dimorphic anaemia and 4 (3.1%) anaemia in hypersplenism. After one unit of packed red cell transfusion the mean increase in Hb in IDA was 1.106gm/dl, in anaemia of ACD was 0.922gm/dl, in anaemia of CKD was 1.015gm/ dl, in anaemia of liver disease was 0.614gm/dl, in anaemia of combined deficiency was 0.925gm/dl and in hypersplenism was 0.367 gm/dl.
Conclusions: Desirable improvement was seen in most of the patients with respect to all haematological parameters and clinical outcome.
Keywords: Packed Red Cells; Anaemia; Indications for Transfusion.
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