Background: The exact cause of leiomyoma which affects at least 5 million women throughout the world is not known. Currently there are only few markers for leiomyoma which includes serum protein, prolactin, CA 125, soluble serum HLA-G, vascular endothelial growth factor and lactate dehydrogenase etc. However a reliable marker is still not found. This study is undertaken to analyse the association of oxidative stress and sialic acid in leiomyoma patients compared with control group.

Methods: This non interventional cross sectional study comprised of 50 study subjects with 25 leiomyoma patients (case group) and 25 healthy individuals (control group). Total antioxidant was estimated by phosphomolybdenum method. Serum sialic acid was measured by using diphenylamine method.

Results: The result showed a significant increase in the sialic acid level in leiomyoma patients (80.51±9.61) in comparison with normal healthy individuals (57.73±7.77) with p=0.05. Also an insignificant correlation of Total antioxidant level [TAC] between case and control group (p= 0.591).

Conclusion: In conclusion, serum sialic acid concentration is significantly increased in leiomyoma patients as compared to healthy control. This suggests a probable clinical use of sialic acid evaluation in future as a marker of leiomyoma. An insignificant correlation between total antioxidant and leiomyoma can be due to less involvement of oxidative stress in the pathogenesis of leiomyoma.

Keywords: Leiomyoma; Sialic Acid; Total Antioxidants; Tumour Marker.