Background: Soft tissue tumors are defined as non epithelial, extra skeletal tissue of the body exclusive of the reticulo-endothelial system, glia, and supporting tissue of various parenchymal organs. Soft tissue tumours constitute a large and heterogenous group of neoplasms. WHO has classified soft tissue tumors in different categories like Adipocytic tumors, Fibroblastic/Myofibroblastic, Fibro-histiocytic, Smooth muscle, Pericytic, Skeletal muscle, Vascular, Chondro-osseous & tumors of uncertain differentiation. These are further subdivided into benign, intermediate & malignant. This study aims to analyze the histopathological findings of soft tissue tumors and their distribution according to age, sex and site of occurrence in patients. Aims and Objectives: To study the macroscopic and microscopic pathology of benign and malignant soft tissue tumour and there clinico-pathological correlation at rural set up. Materials and Methods: The study was conducted in Indian Institute of Medical Sciences Medical College, Warudi Dist. Jalna, from 1st of January 2017 to November 2017. A Cross sectional study of 151 cases of soft tissue tumors were carried out in details. A pretested proforma was used to classify each tumor and details like age, sex, clinical features, gross and microscopic findings were noted. Results: The most common soft tissue tumor in the study were benign tumors (139 cases), followed by malignant (8 cases) and four cases were reported as intermediate. Lipomas were the most common benign tumors accounting for 99 out of 139 cases. Benign peripheral nerve sheath tumors were the next most common tumor accounting for 22 cases. Benign vascular tumors (10) and benign Fibroblastic-Myofibroblastic tumors (5) accounted for 15 cases. Of 10 cases of benign vascular tumor, all cases were of hemangioma. Of 22 benign peripheral nerve sheath tumors, 12 cases were reported as neurofibroma and 10 schwannomas. Of 7 cases of Fibrohistiocytic tumor, 3 cases were benign, 2 cases of intermediate (Dermatofibrosarcoma protuberance) and 2 cases of malignant fibrous histiocytoma (MFH). Of 8 cases of Fibroblastic/Myofibroblastic tumor, 5 cases were of Benign and 3 cases of malignant variant (Two Fibro sarcoma and one low grade fibromyxoid sarcoma). 8 out of 151 cases were malignant tumors, 2 cases were malignant fibrous histiocytoma (MFH) and 2 were fibrosarcoma whereas malignant peripheral nerve sheath tumor (MPNST), Liposarcoma, low grade fibromyxoid sarcoma and Embryonal Rhabdomyosarcoma accounted for one case each. Conclusion: Benign soft tissue tumors outnumbered malignant tumors by a ratio of 17:1. Lipomas were the most common benign tumors and Malignant fibroblastic/Myofibroblastic tumors were the most common malignant tumors in the present study. Most patients with soft tissue neoplasm presented with painless mass. Sarcomas, for the most part develop as deeply located mass. Hematoxylin and eosin stained sections represented the mainstay of diagnosis.

Keywords: Tumors; Hematoxylin; Fibrosarcoma; Parenchymal Organs.