AbstractIntroduction: Among the most widely studied tumour suppressor gene are RB & p53 which express PRB retinoblastoma protein & p53 protein respectively. These proteins control cell cycle and are involved in the inhibition of cell proliferation. Mutation of these proteins produce uncontrolled cell proliferation. Methodology: The detailed history including the duration, site, onset, progression, personal habits and duration of those habits like smoking, beetle quid chewing were noted. The clinical diagnosis was recorded. Results: In our study, the most common location was tongue 48% followed by the BUCCAL mucosa of 34% and the least common was the floor of the mouth 6%. It was observed that 59% of the cases in the age group 50-60 year showed suprabasal p53 positivity. Conclusion: No significant association observed between P53 and age,smoking and tobacco use.
Keywords: Oral Lesions; P53; Tobacco.