Parapharyngeal space is one of the potential facial planes of head and neck that may be involved by various pathological processes:infectious, inflammatory andneoplastic. Neoplastictumours seen at the parapharyngeal space represent less than 1% of all head and neck tumours. Both benign and malignant tumours may arise in this location, majority appears to be benign. Mostparapharyngealspace tumours are salivary gland tumours, neurogenictumours and lymphoreticular lesionswhich comprise nearly 75­80% of all parapharyngeal space tumours. We report a case of Pleomorphic adenoma arising de novo in the parapharyngeal spacewhich is a very rare site of its occurrence. World literature suggests parapharyngeal space lesions account for only 0.5% head and neck tumours and the majority of the minor salivary gland tumours are malignant. Pleomorphic adenoma arising de novo in the parapharyngeal space is of rare occurrence. High index of suspicion and an adequate clearance of the tumour with a cuff of surrounding dispensable normal tissues is the key to successful treatment of such tumours.

Keywords: Parapharyngeal; Salivary Gland Tumour; Pleomorphic; Adenoma.