Introduction: Dengue is the most important arthropod borne viral infection of humans. As there is an alarming rise in Dengue Fever and its complications (i.e, Dengue Hemorrhagic Fever/Dengue Shock Syndrome), rapid and accurate diagnosis is of paramount importance. Aims/Objectives: 1. To study the prevalence of dengue in different age groups and sex distribution. 2. To study the spectrum of clinical symptomatology in endemic population. 3. To evaluate the clinical, hematological, biochemical, serological and coagulation profile in different stages of confirmed Dengue cases. 4. To correlate clinical, hematological, biochemical, serological and coagulation findings with disease severity and clinical outcome. Methods: A prospective study from June 2014 to June 2015 was done among 100 serologically confirmed cases of dengue by rapid immunologic tests. Evaluation of clinical data, hematological and biochemical parameters with peripheral smear study were carried out. Results: A total of 100 serologically positive cases were studied with adults (63%) and children (37%). The commonest clinical presentation was fever (100%), headache (80%), retro­orbital pain (48%), vomiting (18%), myalgia (64%), arthralgia (52%), hemorrhagic manifestation (18%) and shock (06%). The Hematological profile observed were decrease in Hemoglobin (62.5%), Hemoconcentration (35%), Leukopenia (57.5%) with presence of atypical lymphocytes (43.7%). and Thrombocytopenia of varying degree (62%). Liver enzymes were elevated in 25 % of cases and markedly elevated APTT level in 18% of cases of DHF/DSS. Conclusion: Early and prompt diagnosis by rapid diagnostic kits along with clinical features and serial measurements of hematological and biochemical parameters helps in reducing the morbidity and mortality associated with Dengue.

Keywords: Dengue; Dengue Fever; Dengue Hemorrhagic Fever; Dengue Shock Syndrome; Severe Dengue.