Abstract Background: Chronic inflammation is often marked by granuloma formation. This is a diagnostic sign of a plethora of lesions. Individual entities have their respective and unique presentation and hence the need to accurately identify the etiology of individual granulomatous lesion. This has a direct relationship with treatment protocols and hence patient morbidity. With this study we try to understand the various clinical settings and presentations in all the granulomatous lesions encountered in our Department of Pathology, Histopathology, in a year. Materials and Method: Retrospective study of cases diagnosed as granulomatous lesions throughout the body received over a period of 1 year from January 2015 to December 2015. All the lesions reported on histopathology were studied for individual characteristics and etiology with the help of special stains wherever required. Result: Fourty cases of granulomatous lesions were studied at Department of Pathology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India. Most commonly affected age group was 3rd decade and females being most commonly affected with 29 cases (72.50%). Lymph node was the most commonly affected site with 19 cases (47.50%) with tuberculosis predominating the etiologies in 18 cases (45%). Other conditions noted were Leprosy, Fungal infections and Inflammatory conditions. Conclusion: Tuberculosis is the predominant etiological factor behind granulomatous lesions throughout the body, most commonly affecting lymph nodes. Most commonly granulomatous lesion encountered in skin is Leprosy. Fungal infections had considerable share in granulomatous lesions affecting predominantly the head and neck region.
Keyword: Granuloma; Tuberculosis; Organs; Stains.