Purpose: Dysplastic changes in megakaryocytes are important features
of myelodysplastic syndrome (MDS). This study was done to understand
various megakaryocytic alterations including the dysplastic forms in
hematological disorders presenting with thrombocytopenia in non-MDS.
Methods: A prospective study of bone marrow aspiration in 120 patients
with thrombocytopenia was conducted for a period of 1year from July
2019 to June 2020 in Department of Pathology, S.Nijalingappa Medical
College and HSK hospital, Bagalkot, Karnataka to assess the number and morphology of megakaryocytes in non-MDS related thrombocytopenia.
Results: Dysplastic features were observed in 100%, 86.36%, 70.17% &
33.33% cases of acute leukemia, dimorphic anemia, megaloblastic anemia and aplastic anemia respectively. Conclusion: The presence of dysplastic megakaryocytes should not lead to the diagnosis of MDS as it is also common in non MDS related thrombocytopenia. Hence, patients clinical & hematological parameters should always be correlated.
Keywords: Megakaryocytes; Thrombocytopenia; Non-MDS; Bone
marrow.