Needle core biopsies or Tru cut biopsies are the commonly used diagnostic tool in detection of prostatic cancers. It also poses as a major diagnostic challenge in tumour detection in prostate as the diagnosis depends on the size and number of adequate cores. This study conducted at a tertiary care centre in kerala, aims to identify adenocarcinomas of prostate in needle core biopsies received in the department of pathology in a time period of two years, determining its Gleason’s score and correlating it with age of the patients and serum PSA levels. Gleason’s scoring system has evolved over many years and this study is based on the 2005 ISUP Modified Gleason Score. The conduct of this study also was restricted to core biopsies of prostate in indicated patients. The advent of needle core biopsies has brought about a revolution in detecting carcinomas of prostate at an early stage and which can also be attributed to the increasing rate of detection of prostatic malignancies worldwide. Context: In view of increasing incidence of prostatic tumours in men in India, this study was conducted in needle core biopsies of prostate at a Tertiary Care Centre in Mid Kerala. Aims: 1. To identify adenocarcinomas of prostate in needle core biopsies and classify according to its Gleason score. 2. To correlate Gleason’s score with age of the patients and Serum PSA levels. Settings and Design: Department of Pathology,Government TD Medical College, Alappuzha, Prospective Study. Methods and Material: All needle core biopsies of Prostate with a histological diagnosis of Adenocarcinoma of Prostate were included in this study during a period of two years. All tissue cores were processed and H & E stain was done to evaluate and score the tumour according to 2005 ISUP Modified Gleason score. Age and Serum PSA levels were also correlated with the Gleason score. Statistical analysis used: Descriptive Analysis Results: 40 cases of adenocarcinoma prostate in needle core biopsies were studied in a time period of 2 years. Gleason’s score was determined for each patient and they were grouped as Group A,B,C with Gleason score ≤6,7 and ≥8 respectively. 36 out of 40 patients were in the age group of >60 years and they had a higher Gleason’s score as compared to patients who were <60 years of age. Serum PSA levels were available in 29 cases