Introduction: Cholecystokinin, released from the mucosa of the proximal duodenum after fatty meals, is the most important hormone that promotes gallbladder contraction. Motilin aids in interdigestive gallbladder contraction, which occurs in tandem with giant migratory complexes of the intestines every two hours or so. Other peptides including pancreatic polypeptide and somatostatin may affect gallbladder motility. Methodology: After studying the gross features, representative areas were sampled for histopathological examination. The patient’s name, age, sex, parity, diet and clinical features were noted. Some of the cases had been diagnosed clinically and all cases hDad been subjected to ultrasound examination preoperatively. Results: Microscopically, 65 (50%) cases had normal mucosal lining, 38 (29.2%) had atrophied lining, 18 (13.8%) had ulcerated mucosa, eight (6.2%) had hyperplastic lining and one (0.8%) had pyloric gland metaplasia. Wall was infiltrated with lymphocytes, plasma cells, eosinophils, macrophages and showed fibrosis and congested blood vessel. Mild degree of inflammation was seen in 75 (57.70%) cases, 48 (36.90%) had moderate and 7 (5.40%) had severe inflammation. Conclusion: Rokitansky Aschoff Sinuses was seen in all cases. One case with inspissated mucous revealed flattened lining epithelium with mild degree of inflammation. Key words:Chronic Calculus Cholecystitis; Xanthogranulomatous Inflammation; Rokitansky Aschoff Sinuses.