Background: Haematology analyser that determine Platelet indices, such as Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet-crit (PCT) and Platelet large cell ratio (P-LCR) may provide some valuable information regarding the underlying mechanism and pathogenesis of thrombocytopenia.

Methods: Prospective observational study of 200 thrombocytopenic samples, hemogram analysis done byautomated haematology analyser and Statistical analysis was done.

Results: Among the 200 cases of thrombocytopenia,66 cases were classified intohypo productive and 134 cases into hyper-destructive thrombocytopenia. Most common cause of hypo-productive and hyper-destructive was Megaloblastic anaemia(52%) and Dengue(42%) respectively. Both MPV and PDW were increased in hyperdestructive thrombocytopenia compared to hypo productive thrombocytopenia.
Conclusion: Increased MPV and PDW may provide a reliable positive diagnosis of Immune Thrombocytopenic Purpura in case of thrombocytopenic patients.

Keywords: Thrombocytopenia; Immune thrombocytopenia; Platelet indices; Mean platelet volume; Platelet
distribution width.