Introduction: Liver diseases are one of the important public health problems in the world and also in India. The tremendous amount of socio economic burden caused by these liver diseases, it is necessary to study the patho-physiological changes in the coagulation and the same attempt is made to review the normal physiology of haemostasis, the role of the liver in the haemostatic system and to discuss the coagulation abnormalities that may occur in patients with liver disease in this study. Aim: To study the coagulation profile in patients of liver disease.

Objectives:
1. To study the alteration in coagulation profile in various liver diseases which helps to evaluate the risk of bleeding in patients with liver disease.
2. To study the association of coagulation abnormality with the extent of liver disease.
3. To find out prevalence of patients admitted with liver disease.

Material and Methods: The materials for the present study included patients attending the Medicine outpatient department with liver disease may be acute or chronic and admitted in In–patient department of Medicine and I.C.U. of Dr. Shankarrao Chavan Government Medical College, Vishnupuri, Nanded a tertiary care centre. Result: A total of 120 cases were analyzed during the study period. Alcoholic liver disease was the most common pathology amongst the study subjects (44.17%). More than 2/3rd (70%) of the patients included in the study have deranged coagulation test. The total prevalence of liver disease in the hospital was 0.67%.

Keywords: Liver disease; Coagulation; Haemostasis.