Introduction: Gastrointestinal stromal tumors (GIST) are specific, C- Kit (CD117) - positive, mesenchymal tumors of the gastrointestinal tract which encompassing a majority of tumors, previously considered gastrointestinal smooth muscle tumors. Diagnosis is based on histological and immunohistochemical examination characterized by c-kit (CD117,CD34) staining. Objective: To present diversity of presentations of this disease and treatment protocols based on 4 variety of presentations in our case studies. Materials and Methods: We present an analysis of clinical presentation and course, surgical management and pathological features of 4 patients with gastrointestinal stromal tumors treated in our institution. Result: Our results confirm that in stromal tumors complete surgical resection remains the mainstay of treatment in localized gastrointestinal stromal tumors. Discussion and conclusion: Complete removal of the tumor is curative in localized tumours with no recurrence in 2 yrs follow up. In large lesions with metastasis c-kit targeted chemotherapy and surgery gives a better disease free stage.

 Keywords: Gastrointestinal Tumours;  Jejunal GIST; Chronic Intussusception; Imatinib; C-Kit; CD-117.