Wound bed preparation is a challenging, complex art. It can be fined as the process of removing  local barriers which may facilitate healing and provide a more efficient means of wound healing.1  It is a complex process that involves an understanding of the physiology of wound healing, the factors, which disrupt wound healing and methods to overcome them.Diabetic foot ulcer (DFU)
is a debilitating and severe manifestation of uncontrolled and prolonged diabetes that presents  as ulceration, usually located on the plantar aspect of the foot. Standard local and invasive care  along with novel approaches like stem cell therapy pave the way to reduce morbidity, decrease amputations, and prevent mortality from DFU.2  Various modalities have been tried and described for accelerating the wound bed preparation of such wounds. The principles of wound bed preparation can be summarised as TIME an abbreviation stands for Tissue management, Infection control, Moisture regulation, and wound  Edge management. In this article, we discuss the case of an 40 year old male patient who developed right lower limb diabetic foot ulcer from a blister, which progressed to necrotising
soft tissue infection (NSTI) and underwent wound bed preparation for NSTI and regenerative  techniques.