Penile cancer, though rare, presents unique challenges that extend beyond the physical realm, significantly impacting patients' psychosocial well-being. This article explores the psychosocial aspects of penile cancer, including its effects on health and social background, and highlights the crucial role of nurses in providing counselling and guidance. Nurses play a vital role in assessing the psychosocial needs of patients, offering emotional support, providing education and information, addressing body image and sexual functioning concerns, facilitating social support, and ensuring long term follow-up care. By actively engaging in the holistic care of patients with penile cancer, nurses contribute to improving their overall quality of life and well-being.