Context: Many emergencies are there in the life of human being, among that Cardiac arrest being world’s largest killer disease leads to death of around 17.3 million/year in India. Sudden Cardiac arrest needs to be managed with BLS. Nurses are having prime role in providing BLS and need to be trained.

Aim: The overall aim of the study is to assess and train the staff nurses on knowledge and practice skill regarding Basic Life support (BLS).

Setting and Design: Research design for study was pre-experimental one group pretest and posttest design.

Methods and Material: The samples of 30 staff nurses were selected to collect data by using purposive sampling technique. The tool used were demographic variables, structured knowledge Questionnaire regarding BLS, and checklist on BLS to evaluate practical skills.

Statistical analysis used: The collected data were tabulated, analyzed and interpreted by using descriptive and inferential method.

Results: The results showed that in pretest majority 73.3% of staff nurses have average knowledge, 26.7 % having poor knowledge and in posttest majority 80% had developed good knowledge only 20% had average knowledge. In practice skill, the pretest finding revealed that 56.7% staff nurses had good practice skill while most of the staff nurses 43.3% had poor practice whereas in the posttest all 100% had developed good practice skill regarding BLS.

Conclusion: Findings concluded that computer assisted teaching and skill development program were very effective in improving knowledge and skill regarding BLS among staff nurses.