Simulation has been widely adopted as a training and assessment tool in medical education. Conventional teaching methods may be inadequate to properly train healthcare providers for rare but potentially lethal events in Toxicology such as managing associated polytrauma in alcoholic drink and drive cases, Acute Brain stroke due to cocaine toxicity, acute coronary syndrome in Cannabis and cardio-respiratory arrest in Opioid abuse. We have observed that Simulation based training, by enhancing provider skills, can subsequently decrease medical errors and increase patient safety.