Background: Connective tissue disorders also called collagen vascular diseases are caused by deposition of immune complexes or inherited as disorders of bone, skin, cartilage, blood vessels, basement membrane all autoimmune diseases, to some extent, have implications for fertility and obstetrics. Currently, due to available treatments and specialised care for pregnant women with autoimmune disease, the prognosis for both mother and child has improved significantly. However these pregnancies are always high risk. Case Series: We present four cases of successful pregnancy outcomes and one case of ongoing pregnancy in five patients diagnosed with connective tissue disease. Two cases diagnosed with Antiphospholipid antibody syndrome were on aspirin, heparin, and progesterone supplements antenatally and postnatally on heparin have successful outcome. One case diagnosed with Antiphospholipid antibody syndrome is on aspirin and heparin is continuing her pregnancy. One case Diagnosed with Systemic lupus erythematosis was on tab azathioprine, tab chloroquine, steroids antenatally and postnatally has successful outcome. One case diagnosed with Sjogren syndrome was on steroids before and after delivery has successful outcome. Conclusion: Pregnancy in most of these women is at high risk for maternal and perinatal complications. Preconceptional counseling, appropriate medication, multidisciplinary care, delivery in tertiary care hospital with specialist can result in favourable outcome.