Background: Cervical cancer is the commonest cause of death in reproductive age group women, next to breast cancer. Cervical cancer is routinely screened by Papanicolaou (PAP) smear test. However e levels of oxidants, antioxidants and enzymes have been assayed and studied to screen as well as to decide the prognosis in pre malignancy and in cervical cancer, as an alternative. Aims and Objectives: To estimate the serum levels of liver enzymes Gamma-glutamyltransferase (GGT) and Glutathione–S- transferase (GST) in the serum of patients who have undergone PAP smear screening test or HPV testing, and to correlate the levels of GGT and GST with PAP smear results. Materials and Methods: A cross-sectional observational hospital based study was conducted in which the serum GGT and GST was estimated in 19 patients with PAP smear test report positive cervical intraepithelial neoplasia (cases) and 51 patients with PAP smear test report negative for cervical intraepithelial neoplasia (controls). Results: Median serum GGT level did not show significant difference between cases and controls (P=0.491 NS) whereas GST levels showed a highly significant difference between cases and controls (P=0.005 HS). Conclusion: Based on our pilot study, serum GGT and GST levels were lower in newly diagnosed PAP smear positive cases compared to PAP smear negative controls but only serum GST showed statistical significance. As this study is a pilot study, more studies need to be conducted before coming to a strong conclusion.

Keywords: GGT; GST; Cervical Intraepithelial Neoplasia; Pap smear.