Aim: To determine the efficacy and safety of Depot 17-α hydroxyprogesterone caproate and Human chorionic gonadotropin (hCG) in the management of threatened abortion. Setting and Design: This is a prospective comparative study in cases of threatened abortion in the first trimester. Material and Method: Use of Inj.hCG and Inj. depot 17-α Hydroxyprogesterone caproate studied in a randomized group of 80 pregnant women, diagnosed cases of threatened abortion in the first trimester. Result: In the present study Inj.hCG found comparatively better in cases of threatened abortion in a first trimester.

Keywords: Threatened Abortion; 17-α Hydroxyprogesterone Caproate; hCG.