The cross sectional study was performed to find out the prevalannce of sickle cell anemia in tribal population of Thane district; Maharashtra from July 2012 to December 2013. The study was conducted at GMC & Sir JJ group of hospitals; Mumbai. In this study we screened 1524 tribal subjects comprising adult men & women as well as children. Whole blood Samples were collected in EDTA bulb in different camps organized in PHC & RH centres located in tribal region of Thane as well as samples were also transported by health workers from these tribal areas health centres to Biochemistry special investigation laboratory. Samples were analysed by Automated High Perfomance Liquid Chromatography analyser. We found that 11% of tribal population was having sickle cell trait & 0.5% of were suffering from sickle cell disease.

Keywords: Sickle Cell Anemia; HPLC; Tribal Community; Chromatograph.