Hepatitis E is one of the common forms of acute viral hepatitis in epidemic proportions in India. It has been seen to cause severe Haemolysis when associated with G6PD deficiency which is rarely seen in the northern India. This case report is of a 35 year old male with Hepatits E who presented to the Emergency Room pale and icteric and on evaluation was found to have G6PD deficiency as the cause of severe haemolysis. Therefore, in patients with acute viral hepatitis and severe anaemia with unconjugated hyperbilirubinemia, it becomes a necessity to rule out G6PD deficiency as a cause of the intravascular haemolysis.

Keywords: G6PD Deficiency; Hepatitis E; Viral Hepatitis; Intravascular Haemolysis; Unconjugated Hyperbilirubinemia; Anaemia.