Fat embolism syndrome is a rare clinical complication of fat embolism which occurs in almost 90% of long bone fractures. Incidence of FES is around 0.2 to 2.5 % in overall cases of fat embolism. Its diagnosis is mainly clinical characterized by triad of respiratory, dermatological and neurological manifestations. We are presenting a case of 20 year young male who suffered traumatic left femoral shaft fracture in RTA. After uneventful 24 hours patient suddenly developed altered sensorium in absence of any respiratory or dermatological manifestation. He was confirmed to have CFE after series of brain imaging and was then managed conservatively for the same to which he responded well.

Keywords: Cerebral Fat Embolism; Fat Embolism Syndrome; Major Trauma; Traumatic Brain Injury.